Advances in Botanical Research, Vol. 14 by J. A. Callow

By J. A. Callow

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Pollock, R. A. and Rosenberg, L. E. (1986). Cell 44,451-459. Hurt, E. C. and Schatz, G. (1987). Nature Lond. 325,499-503. Hurt, E. C. and van Loon, A. P. G. M. (1986). Trends in Biochem. Sci. 5,204-207. Hurt, E. , Muller, U. and Schatz, G. (1985a). EMBO J . 4, 3509-3518. Hurt, E. , Oppligeler, W. and Schatz, G. (1985b). EMBO J . 4, 2061-2068. Hurt, E. , Rochaix, J-D. and Schatz, G. (1986). EMBO J . 5 , 1343-1350. , Richardson, W. , Markham, A. T. and Smith A. E. (1984a). Nature Lond. 311, 33-38.

A second pathway for the formation of HMG-CoA has been established in bacteria, animals and fungi. In this pathway, HMG-CoA is an intermediate in the degradation of the branched-chain amino acid leucine, leading ultimately to acetyl-CoA and acetoacetate (Fig. 2). , 1980) and into sterols and sesquiterpenoids in tissue cultures (Ryder and Goad, 1980; Anastasis et a f . , 1983, 1985). However, detailed examination by "C-nmr spectroscopy of the labelling patterns of the isoprenoids synthesized from [''CC]leucine in tissue cultures of Androgruphis paniculuta indicated that the leucine was degraded to acetyl-CoA and acetoacetate before incorporation into the isoprenoid compounds (Anastasis ef a f .

V. and Laskey, R. A. (1982). Cell 30,449-458. , Dilworth, S. , Black, S. , Kearsey, S. , Cox, L. S. and Laskey, R. A. (1987). EMBO J. 6,69-74. PROTEIN TARGETING 23 Douglas, M. , McCammon, M. T. and Vassarotti, A. (1986). Microbiol. Rev. 50, 166-178. Eilers, M. and Schatz, G. (1986). Nature Lond. 322, 228-232. Ellis, R. J. (1981a). Ann. Rev. Plant Physiol. 32, 111-137. Ellis, R. J. (1981b). Biochem. SOC. Symp. 46,223-234. Ellis, R. J . (1983a). Subcell. Biochem. 9 , 237-261. Ellis, R. J. (1983b).

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