By George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)
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This antigen has been localized in the perinuclear region of cells infected with a strain of adenovirus type 2 carrying a defective SV40 genome (AdB'ND,). Sera from monkeys immunized with cells infected with Ad2+ND, react with an intranuclear antigen present in both SV40-transformed and SV40infected cells (Lewis and Rowe, 1971). Antibody to U-antigen is also detected in sera from SV40 tumor-bearing hamsters. I n contrast to Tantigen, U-antigen is heat-stable. The existence of U-antigen and the difficulty in obtaining specific antisera (Lewis and Rowe, 1971) reveal that future studies aimed at characterizing T-antigen will need to be carefully designed and evaluated.
It is not known whether sera prepared in hamsters against trypsinized normal, polyoma-transformed, or spontaneously oncogenic cells will react with nontrypsinized SV40-transformed cells. Such tests would help clarify a possible identity between normal cell antigens and SV40 S-antigen. The L‘normal” cell antigen is not a Forssman antigen such as that described by Robertson and Black (1969), because extensive treatment of SV40 S-antisera with sheep red blood cells failed to adsorb antibody against the normal cell antigen (Hayry and Defendi, 1970).
PAPOVAVIRUS SV40 23 80,000 by use of an immunoabsorbent (Del Villano and Defendi, 1970). , 1967). The biological function of T-antigen remains obscure. , 1969). This antigen has been localized in the perinuclear region of cells infected with a strain of adenovirus type 2 carrying a defective SV40 genome (AdB'ND,). Sera from monkeys immunized with cells infected with Ad2+ND, react with an intranuclear antigen present in both SV40-transformed and SV40infected cells (Lewis and Rowe, 1971). Antibody to U-antigen is also detected in sera from SV40 tumor-bearing hamsters.